Epithalon file, Professor Vladimir Khavinson


Professor Vladimir Khavinson discovered, with its scientific team, the effects of Epithalon and different ways to synthesize it. He has conducted numerous scientific and clinical studies with this tetrapeptide in the past 15 years.

# Extracts from press articles:

-1- Live to 100 says Russian physician:

“The great secret of Khavinson for a more lasting existence is the action of peptides (biomolecules formed by connecting two or more amino acids by peptide bonds between an amine group of an amino acid, and a carboxyl group of another amino acid). The survey began 35 years ago at the Military Medical Academy in the former Soviet Union.

The graphics and data produced by the Russian in the Congress put an end to doubts. The results of tests performed with peptides by the doctor and his staff were all leaders, without exception. With success in experiments with rats, monkeys and humans, it was proved that peptides potentiate cell division, stimulate brain activity, promote the reduction of tumors and more.
“There isn’t even the possibility of an allergic reaction,” said the researcher.

“There is no stimulation or inhibition of processes, the peptides only regulate the body. They are natural substances, they do their work without disturbing the body. These bioregulators are absorbed by the body to repair only functions. There’s no chance of overdose and toxicity. They act specifically on the target organ,” he said, who also announced the soon release of a product line based on the new “heroes of longevity.” The prognosis is that by 2020, the therapy can be practiced on a larger scale.

“More than 15 million people have been treated with these bioregulators, always showing 100% positive feedback. The protein synthesis is more powerful. A cell that normally divides 50 times has its capacity increased by almost 50% with peptides.
In one test, the application of peptides in the elderly for 12 years brought declines in mortality and also restored the level of various hormones, such as melatonin – which reached levels only reported in human youth. There was also a great improvement in immunity, brain function and bone density, not to mention the reduction of respiratory diseases,” Khavinson pointed out.

At the UN :
On October 1st, Khavinson presented his study to the world for the first time during the celebrations for the United Nations “Day of the Elderly” in the United Nations Palace in Geneva, Switzerland. At the time, ten countries invited him to work as a consultant in their respective ministries of health. “If it depended on me, the whole world would know about the barriers we are ready to surpass,” said the scientist.”

-2- A Russian gerontologist is certain that the normal human life span is 120 years:

“April 3, 2012, Svetlana Smetanina. When Sophia Loren posed for a Pirelli calendar at 71 a few years ago, the remarkable actress must have had no idea that she was going to foment a revolution. She proved that you can look so good even in your seventies that they invite you to be a pin-up for a calendar that is famous for shooting only most stunning beauties. Russian gerontologist Vladimir Khavinson, who heads the International Association of Gerontology and Geriatrics, is certain that the normal life span of a human being is 110-120 years.

Vladimir Khavinson explains that all organs and tissues have reserve cells, or stem cells. That’s how nature arranged it – for injuries or some other needs. These are “spare parts.” After devastating diseases, such as strokes or heart attacks, your body has a chance to restore its capacity using the spares. These “reserve” cells make up about 30-40 percent of each organ. If all of them are used properly, a person lives to 100-110.

But the thing is that, for most people, these cells fail to work. They are not activated for various reasons – poor living conditions, bad environment, smoking and drinking. We waste the reserves that nature granted us to live longer. However, while we can give up smoking or alcohol, you can never get away from the stress and bad environment of a big city, if that is where you live.”


-3- Anti Ageing Conference, London 2012:

“Professor Khavinson is the President of the International Association of Gerontology and Geriatrics, European Region; Vice–President of the Gerontological Society of the Russian Academy of Sciences, Director of the Saint-Petersburg Institute of Bioregulation and Gerontology, Member of the Russian Academy of Medical Sciences, the main specialist in gerontology and geriatrics of the Health Committee and adviser of the Committee for Social Policy of the Government of St. Petersburg.

Since 1971 V. Khavinson has been engaged in studying of the role of peptides in regulation of the mechanisms of ageing, design, preclinical and clinical study of new peptide geroprotectors. His 35-year long investigations resulted in elaboration of a method for complex application of peptide bioregulators to slow down ageing and increase average life span. 6 peptide pharmaceuticals and 36 biologically active supplements developed by V. Khavinson have been introduced into clinical practice.

V. Khavinson is the author of over 700 publications, however, the major achievements are summarized in his books “Gerontological aspects of genome peptide regulation” (Karger AG, 2005) and “Peptides and Ageing” (NEL, 2002). He is the author of 189 Russian and International patents.

The treatment of elderly and senile persons with peptides improved physiological functions, and reduces the lethality by 44-49% over 15 years of clinical observation.

Thus, some interactions peptide-DNA epigenetically controlled genetic and cellular functions may be responsible for the recovery of homeostasis, and the extension of life. They seem to play an important role, even in the early stages of the origin of life and evolution.”

# His personal website:

www.khavinson.ru, there you’ll find his C.V., a long list of his international patents, the long list of his scientific publications, and many other free documents.

# His scientific publications:

see the complete list: www.khavinson.ru/publications
– 10 livres
– 137 published scientific articles
– 171 other publications

(Note : You will notice that at the beginning he used the spelling “Epithalone” while scientists now use the spelling “Epitalon” or “Epithalon.” The reason is that this term does not exist, and it is the phonetic translation of the Russian word given by Professor Khavinson to this peptide which he invented.
As long as this word is not entered in a western dictionary his spelling will still be random. What a surprise that this revolutionary product is not yet sufficiently known to the Western world to be integrated into the scientific vocabulary. Should we see a “boycott” anti-Soviet, or the hope that humanity can not take advantage of this treatment against body aging, everyone can do his opinion, for me I think it is a mixture of the two.)

# A selection from his publications concerning Epithalon :

The complete list

– Article from 2003 : “Epithalon Peptide Induces Telomerase Activity and Telomere Elongation in Human Somatic Cells”, Buy at springer.com

– Article from 2009 : “Peptide Regulation of Aging: 35-Year Research Experience” Buy at springer.com
Vladimir Khavinson and Vladimir Anisimov. Bulletin of biology and experimental medecine, July 2009. Version visible online www.khavinson.ru/peptide-regulation-of-ageing

– Article from 2011 : “Morphofunctional fundamentals for peptide regulation of aging”, Buy on springer.com

– Article from 2002 : “Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa”, Free on khavinson.ru

– Article from 2002 : “Effect of Epitalon on Interleukin-1ß Signal Transduction and the Reaction of Thymocyte Blast Transformation Under Stress”, Free on khavinson.ru

– Article from 2001 : “Epitalon stimulates melatonin production and restores circadian rhythm of cortisol in old rhesus monkeys”, Free on khavinson.ru

– Article from 2001 : “Synthetic tetrapeptide epitalon restores disturbed neuroendocrine regulation in senescent monkeys”, Free on khavinson.ru

– Article from 2003 : “Epitalon and colon carcinogenesis in rats: Proliferative activity and apoptosis in colon tumors and mucosa”, Free on khavinson.ru

– Article from 2003 : “Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice”, Free on khavinson.ru

– Article from 2003 : “Effect of Epithalon in Campbell Rats of Various Ages”, Free on khavinson.ru

– Article from 2002 : “Epitalon influences pineal secretion in stress-exposed rats in the daytime”, Free on khavinson.ru

– Article from 2000 : “Regulating Effect of Epithalone on Gastric Endocrine Cells in Pinealectomized Rats”, Free on khavinson.ru

– Article from 2000 : “Effect of epitalon on the lifespan increase in Drosophila melanogaster”, Free on khavinson.ru

– Article from 2000 : “Effect of Epithalone on the Age-Specific Changes in the Time Course of Lipid Peroxidation in Drosophila melanogaster”, Free on khavinson.ru

– 144 pages book: “Peptides and Aging”, 54 USD

– 104 pages book: “The interrelation between life span and peptide regulation of gene activity”, 139 USD

– 578 pages book: “The Pineal Gland and Cancer: Neuroimmunoendocrine Mechanisms in Malignancy”, 195 USD

– 336 pages book: “Modulating Aging and Longevity”, 175 Euros
“Changes of aging and longevity associated with small peptides”

– free PDF: “Institut of Gerontology and Bioregualtion of St Petersburg”,

# The patents concerning Epithalon :

Complete list of his patents

Tetrapeptide revealing geroprotective effect, pharmacological substance on its basis, and the method of its application:
US Patent : US 6727227. January 20, 2000.

Tetrapeptide L-alanyl-L-gluthamyl-L-asparagyl-glycine of the general formula L-Ala-L-Glu-L-Asp-Gly is proposed as a biologically active compound revealing a geroprotective effect. The use of L-Ala-L-Glu-L-Asp-Gly tetrapeptide in medicine is proposed for preparing a substance revealing a geroprotective effect. There is proposed a pharmacological substance, which contains as its active base an effective amount of tetrapeptide of the formula L-alanyl-L-gluthamyl-L-asparagyl-glycine (L-Ala-L-Glu-L-Asp-Gly) or its salts of the amino group (acetate, hydrochloride, oxalate) and of carboxyl groups (the salts of metals – Natrium, Potassium, Calcium, Lithium, Zinc, Magnesium, and also the salts of organic and inorganic cations – ammonium and triethylammonium). The substance is proposed for parenteral, intranasal, oral administration, and local application. With respect to the invention, the method of premature ageing prevention implies prophylactic and/or therapeutic administration to a patient of the pharmacological substance in doses 0.01 to 100 mu g/kg of the body weight at least once a day for a period necessary for the achievement of a therapeutic effect.

– The French version: “Tétrapeptide ayant un effet géronto-protecteur, substance pharmacologique à base de ce dernier, et procédé d’application” EP 1179008 B1