Epitalon against cancer

During the year that has just passed since we made Epitalon available to the general public, we have received several testimonials of healed cancer after using our Pur Epitalon.
Even people with terminal cancer have been cured of their cancer, using doses ranging from 8mg to 50mg per day. There are no recommended dose as each case is different and each individual will react differently. We suggest you consult a medical professionnal for advice.

We hesitated a long time before communicating on this particular aspect of Epitalon, as cancer is the number one taboo subject for the medical industry.
Here are 2 numbers that will help you realise how important the Cancer Business is, and why they don’t want us to get cured:
– Costs of cancer totaled 264 billion USD, in 2010 in USA, source Research America
– Costs of cancer totaled 126 billion Euros, in 2009 in European Union, source The Lancet

But still we decided to do a review of scientific studies that have already been published regarding the effectiveness of Epitalon against cancer and cancerous cells.

There are already several scientific books (see below), and more than 20 studies that have been published on PubMed alone, answering the keywords epithalon-cancer.

Here are some excerpts on this subject:

Pineal Gland and Cancer — An Epigenetic Approach to the Control of Malignancy: Evaluation of the Role of Melatonin.


Full version free online here

Excerpts: The secretion of the pineal hormone melatonin is under control of the hypothalamic suprachiasmatic nuclei, the seat of the central circadian clock, and conveys information concerning time of day as well as season to practically all parts of the body. This means that melatonin is an integral part of the circadian time-keeping system.
According to the summarized findings a link exists between the pineal gland and cancer, a mutual and dynamic interaction between the secretion of melatonin and malignant growth. A fresh tumor is “sensed” by the pineal gland via neuroimmunoendocrine changes leading to a stimulation of melatonin secretion which in turn activates endogenous defence processes. At this stage of cancer development melatonin can exert a direct tumor-inhibitory activity.

Note: You can find 174 studies cited at the end of this publication. Epitalon decalcifies and stimulates the pineal gland, allowing it to produce melatonine, that’s one of the mechanisms that make it successful against cancer, and that’s why people taking Epitalon can recover their deep sleep pattern, an essential factor in body immunity and repair.

– Book: Pineal Gland and Cancer — Neuroimmunoendocrine Mechanisms in Malignancy. 2011

Buy this book online for 90 USD or read some parts for free here

Excerpts: The link between the pineal gland and cancer is a rapidly emerging research field due to promising experimental and clinical trials with melatonin. The pineal gland acts as a transducer of environmental light to regulate rhythmic processes, including reproductive function in seasonally breeding animals and the entrainment of circadian rhythms, such as the sleep-wake cycle, in man. This book elucidates the physiological significance of the pineal gland and surveys phenomena and mechanisms of pineal – tumor interaction at the neuroendocrine, neuroimmune, neural, and molecular levels.
Three years ago, most authors contributing to this book gathered at the Heinrich Fabri Insitute of the University of Tubingen at Blaubeuren near Ulm in Germany for the third conference on “Pineal Gland and Cancer”.
It was in Vienna during the 1930s and 1940s that W.Bergmann and P.Engel demonstrated that pineal extracts possess growth inhibitory properties on experimental rodent tumors and R.Hofstatter reported favorable results when these extracts were given to cancer patients.
Initial clinical applications of the pineal hormone for incurable cancers raise hopes for a promising future use, particularly when combined with other therapies (e.g., interleukin-2) increasing their efficacy and reducing their toxicity.
We hope that this book will help those working in this field to link the pineal gland and cancer and encourage others from diverse areas to join and thus enrich this field of research. The interplay between the pineal gland and malignancy has to be viewed in the chronobiologic framework of the largely epigenetic, highly complex, and non-lineary organized psychoneuroimmunoendocrine network as well as progressing genomic aberrations within the tumor.

Note: This group of research seems unfortunately to be mostly focussed on the role of Melatonin, the pineal hormone, but discuss also some publications about Epithalamin from page 294-303. My opinion is that they are trying to “drown the fish”, meaning that they focuss their research on Melatonin, a very complex subject, instead of going right to the point, taking the shortcut to curing cancer that is much faster with the use of Epitalon!
As usual in modern science and medical research, the but is to find new ways to treat the symptoms and multiply the number of drugs to take, instead of curing the source of the problem… The pineal gland produces much more than just melatonin. They should have called their book “Melatonin and cancer”!


– Book: Experimental Studies of the Pineal Gland Preparation Epithalamin. 2001

Buy this book online for 70 USD

Abstract: Twenty-five years of study have shown a wide spectrum of high biological activity of the pineal peptide preparation epithalamin. Long-term exposure to epithalamin was followed by an increase in the mean and maximum life spans and slower rates of aging of rats, mice, and D. melanogaster. Epithalamin increases pineal synthesis of serotonin, N-acetylserotonin, and melatonin and night pineal secretion of melatonin in adult and old rats. The pineal preparation decreases the luteinizing hormone and prolactin levels in adult male rats as well as the threshold of the hypothalamopituitary complex to feedback inhibition by estrogens in old female rats; it slows dawn age-related cessation of estrous function in rats and induces the recurrence of estrous cydes and fertility in old, persistently estrous rats.
Epithalamin increases the levels of triiodothyronine and decreases thyroxine in serum of adult rats. It further decreases the levels of corticosterone in the serum of mice and increases the susceptibility of the hypothalamo-pituitary complex to the homeostatic inhibition of adrenocorticotropic function by glucocorticoids in old rats.
Serum insulin and triglyceride levels in rabbits are decreased by epithalamin and the tolerance to glucose and diuresis are increased.
With respect to immune function, it was found that T and B cell-mediated immunity in adult and old mice as well as the titer of thymic serum factor and the titer of thymosin-like compounds in old mice are stimulated by the pineal peptide preparation in the same way as the colony-forming activity of splenocytes in pinealectomized rats.
Epithalamin inhibits spontaneous and induced carcinogenesis and is a potent antioxidant, decreasing lipid peroxidation and stimulating the activity of CuZn superoxide dismutase.
The obtained results demonstrate a high efficiency of epithalamin therapy for prophylaxis of age-related pathology, including cancer, showing a new physiological way to slow down pathological processes and to extend human life spans.

Note: epithalamin and epitalon are equivalent, epitalon being the non-animal tetrapeptide version.



Buy this book online for 78 USD

Abstract: A technology has been developed for manufacturing of biologically active complex peptide preparations from extracts of different tissues. In particular, the pineal preparation (Epithalamin) augments the in vitro outgrowth of explants from the pineal gland but not from other tissues, the latter being stimulated by peptide preparations from respective tissues.
Epithalamin increases melatonin production by the pineal gland of rats, improves immunological parameters in rats and mice, produces anticarcinogenic effects in different experimental models, stimulates antioxidant defenses, and restores the reproductive function in old rats.
These effects are combined in the ability of Epithalamin to increase the lifespan in rats, mice, and fruit flies. Many of these effects are reproduced in clinical trials, which have demonstrated the geroprotector activity of Epithalamin in humans.
Interestingly, for eye retina and the pineal gland, a common tetrapeptide Ala-Glu-Asp-Gly (Epitalon) has been designed, probably reflecting the common embryonal origin of these two organs. Epitalon reproduces the effects of Epithalamin including those related to its geroprotector activity. In particular, Epitalon increases the lifespan of mice and fruit flies and restores the circadian rhythms of melatonin and cortisol production in old rhesus monkeys.
At the same time, Epitalon prolongs the functional integrity of the eye retina in Campbell rats with hereditary Retinitis Pigmentosa and improves the visual functions in patients with pigmental retinal degeneration. Changes in gene expression were observed to be produced by the short peptide preparations.
Therefore, the effects of Epitalon are suggested to be mediated by transcriptional machinery common for the pineal gland and the retina and, probably, for regulation of melatonin production in fruit flies. Based on three decades of studies of the peptide preparations, the peptide theory of ageing has been put forward. According this theory, ageing is an evolutionary determined biological process of changes in gene expression resulting in impaired synthesis of regulatory and tissue-specific peptides in organs and tissues, which provokes their structural and functional changes and the development of diseases.
Correspondingly, correction of such disorders by means of stimulation of peptide production in the organism or through their delivery can promote the normalisation of disturbed body functions.


– Book: Gerontological aspects of genome peptide regulation. 2005

Read part of this book online for free at Google Books here

Excerpts: Chapter “Effect of Peptides on Carcinogenesis in Transgenic Mice”.
The anticarcinogenic activity of Vilon (Lys-Glu) and Epitalon (Ala-Glu-Asp-Gly) was studied in transgenic female FVB mice bearing the mammary cancer gene HER-2/neu.
The transgenic mice, starting from 2 months age, were administred subcutaneously with either 0.1ml of 0.9% NaCl solution (control) or Vilon or Epitalon (only 1 microngram per mouse). The injections were made during 5 successive days monthly. The results are given in Table 3.
These data suggest that suppression of mammary carcinogenesis in transgenic mice by Epitalon is mediated by the inhibition of the HER-2/neu oncogene expression.
A neuroendocrine component prevails in the effects of Epithalamin and Epitalon. Furthermore, possible interactions between the neuroendocrine and immune systems must also be taken into account. In particular, melatonin reveals an immunomodulatory activity. Stimulation of melatonin production by Epithalamin and Epitalon make it plausible that the in vivo effects of Epitalon in particular on HER-2/neu gene expression are mediated by melatonin. Moreover, that antitumor effect of melatonin is especially pronounced in respect to hormone-dependent tumors, such as mammary adenocarcinomos.

Note: The following chapter in this book is also very interresting as it deals with the positive effects of Epitalon against Chromosome Aberrations in cells!

# The publications listed on PubMed on Epitalon against Cancer:

-1. Biological stability evaluation of the a2B1 receptor imaging agents: diamsar and DOTA conjugated DGEA peptide.
Huang CW, Li Z, Cai H, Shahinian T, Conti PS. Bioconjug Chem. 2011 Feb 16;22(2):256-63. doi: 10.1021/bc100388g. Epub 2011 Jan 18.
PMID: 21244039

-2. [The use of peptide bioregulators for cancer prevention: results of 35 years of research experience and perspectives].
Anisimov VN, Khavinson VKh. Vopr Onkol. 2009;55(3):291-304. Review. Russian. No abstract available.
PMID: 19670728

-3. Geroprotective effect of ala-glu-asp-gly peptide in male rats exposed to different illumination regimens.
Vinogradova IA, Bukalev AV, Zabezhinski MA, Semenchenko AV, Khavinson VKh, Anisimov VN. Bull Exp Biol Med. 2008 Apr;145(4):472-7.
PMID: 19110597

-4. Effect of Ala-Glu-Asp-Gly peptide on life span and development of spontaneous tumors in female rats exposed to different illumination regimes.
Vinogradova IA, Bukalev AV, Zabezhinski MA, Semenchenko AV, Khavinson VKh, Anisimov VN. Bull Exp Biol Med. 2007 Dec;144(6):825-30.
PMID: 18856211

-5. [The effect of heavy metal ions and peptide bioregulators on the expression of chromosome fragile sites in the individuals of different age groups and breast cancer patients].
Dzhokhadze TA, Ganozishvili MN, Lezhava TA. Georgian Med News. 2008 Sep;(162):11-4. Russian.
PMID: 18830022

-6. Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice.
Kossoy G, Anisimov VN, Ben-Hur H, Kossoy N, Zusman I. In Vivo. 2006 Mar-Apr;20(2):253-7.
PMID: 16634527 – Free Article

-7. [Effect of epitalon and melatonin on life span and spontaneous carcinogenesis in senescence accelerated mice (SAM)].
Anisimov VN, Popovich IG, Zabezhinskii MA, Rozenfel’d SV, Khavinson VKh, Semenchenko AV, Iashin AI. Vopr Onkol. 2005;51(1):93-8. Russian.
PMID: 15909815

-8.[The influence of substances revealing geroprotective of spontaneous carcinogenesis in mice].
Popovich IG. Adv Gerontol. 2004;14:105-13. Review. Russian.
PMID: 15559508

-9. Stressors and antistressors: how do they influence life span in HER-2/neu transgenic mice?
Semenchenko GV, Anisimov VN, Yashin AI. Exp Gerontol. 2004 Oct;39(10):1499-511.
PMID: 15501020

-10. Expression of argyrophilic proteins in the nucleolar organizer regions of human thymocytes and thymic epitheliocytes under conditions of coculturing with vilon and epithalon peptides.
Raikhlin NT, Bukaeva IA, Smirnova EA, Yarilin AA, Sharova NI, Mitneva MM, Khavinson VKh, Polyakova VO, Trofimov AV, Kvetnoi IM. Bull Exp Biol Med. 2004 Jun;137(6):588-91.
PMID: 15455093

-11. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice.
Anisimov VN, Khavinson VKh, Popovich IG, Zabezhinski MA, Alimova IN, Rosenfeld SV, Zavarzina NY, Semenchenko AV, Yashin AI. Biogerontology. 2003;4(4):193-202.
PMID: 14501183

-12. Epitalon and colon carcinogenesis in rats: proliferative activity and apoptosis in colon tumors and mucosa.
Kossoy G, Zandbank J, Tendler E, Anisimov V, Khavinson V, Popovich I, Zabezhinski M, Zusman I, Ben-Hur H. Int J Mol Med. 2003 Oct;12(4):473-7.
PMID: 12964022

-13. The role of pineal gland in breast cancer development.
Anisimov VN. Crit Rev Oncol Hematol. 2003 Jun;46(3):221-34.
PMID: 12791421

-14. Epithalon decelerates aging and suppresses development of breast adenocarcinomas in transgenic her-2/neu mice.
Anisimov VN, Khavinson VKh, Alimova IN, Semchenko AV, Yashin AI. Bull Exp Biol Med. 2002 Aug;134(2):187-90.
PMID: 12459848

-15. Epithalon inhibits tumor growth and expression of HER-2/neu oncogene in breast tumors in transgenic mice characterized by accelerated aging.
Anisimov VN, Khavinsov VKh, Alimova IN, Provintsiali M, Manchini R, Francheski K. Bull Exp Biol Med. 2002 Feb;133(2):167-70.
PMID: 12428286

-16. Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2/neu transgenic mice.
Anisimov VN, Khavinson VK, Provinciali M, Alimova IN, Baturin DA, Popovich IG, Zabezhinski MA, Imyanitov EN, Mancini R, Franceschi C. Int J Cancer. 2002 Sep 1;101(1):7-10.
PMID: 12209581

-17. [Effect of Epitalon and Vilon treatment on mammary carcinogenesis in transgenic erbB-2/NEU mice].
Alimova IN, Bashurin DA, Popovich IG, Zabezhinskii MA, Volkov MA, Provinciali M, Franceschi C, Khavincon BKh, Anisimov VN. Vopr Onkol. 2002;48(1):57-60. Russian.
PMID: 12101568

-18. Inhibitory effect of peptide Epitalon on colon carcinogenesis induced by 1,2-dimethylhydrazine in rats.
Anisimov VN, Khavinson VKh, Popovich IG, Zabezhinski MA. Cancer Lett. 2002 Sep 8;183(1):1-8.
PMID: 12049808

-19. [Effect of vilon and epithalone on induction and growth of induced bladder neoplasms in rats].
Pliss GB, Mel’nikov AS, Malinin VV, Khavinson VKh. Vopr Onkol. 2001;47(5):601-7. Russian.
PMID: 11785104

-20. [Effect of epithalone on growth kinetics and functional morphology of M-1 sarcoma].
Khavinson VKh, Iuzhakov VV, Kvetnoi IM, Malinin VV. Vopr Onkol. 2001;47(4):461-6. Russian.
PMID: 11710291

-21. [Effect of pineal peptide on parameters of the biological age and life span in mice].
Anisimov VN, Khavinson VKh, Zavarzina NIu, Zabezhinskii MA, Zimina OA, Popovich IG, Shtylik AV, Arutiunian AV, Oparina TI, Prokopenko VM. Ross Fiziol Zh Im I M Sechenova. 2001 Jan;87(1):125-36. Russian.
PMID: 11227856